空间及特殊环境骨骼系统健康科学与工程研究室

Lab of Space&Special Environment for Skeletal System Health Science and Engineering
2016年研究成果

一、英文期刊论文

  1. Hui-Yun Xu, Ruo-Fei Liu, Dan-Dan Ning, JianZhang, Rui-Xin Yang, Manuel A Riquelme, Jinigbao Li, Jean X. Jiang, PengShang*. Biological responses of osteocytic connexin 43 hemichannels tosimulated microgravity.Journal of Orthopaedic Research, Inpress.

  2. Ren L, Wang Z, HuangLW, Yang PF, Shang P*. Technologies for strain assessment from whole bone tomineralized osteoid level: a critical review. Journal of Mechanics inMedicine and Biology, 2016, 16, 1630002 (18 pages).


二、专著

  1. 商澎,杨鹏飞,吕毅,等,编著,《空间生物学与空间生物技术》,西北工业大学出版社,2016

2015年研究成果

一、英文期刊论文

  1. Li Ren, Peng-Fei Yang,Zhe Wang, Jian Zhang, Chong Ding, Peng Shang*. Biomechanical and biophysicalenvironment of bone from the macroscopic to the pericellular and molecularlevel. Journal of the Mechanical Behavior of Biomedical Materials,2015, 50, 104-122.

  2. Ling-Wei Huang, Li Ren,Peng-Fei Yang, Peng Shang*. Response of osteoblasts to the stimulus of fluid flow.CriticalReview in Eukaryotic Gene Expression, 2015, 25(2): 153-162.

  3. Peng-Fei Yang, AndreasKriechbaumer, Kirsten Albracht, Maximilian Sanno, Bergita Ganse, Timmo Koy,Peng Shang, Gert-Peter Brüggemann, Lars Peter Müller, Jörn Rittweger*. On therelationship between tibia deformation and regional muscle contractions inhumans in vivo. Journal of Biomechanics,2015, 48(3): 456-464.

  4. Yi Lv, Peng Shang*. Anilluminated growth system for the study of Arabidopsis thaliana duringdiamagnetic levitation by a superconducting magnet.Advance in Space Research,2015, 55(1): 525-533.

  5. Jian Zhang, Yong Zhao*,Peng Shang*. Responds of bone cells to microgravity: ground-based research,MicrogravityScience and Technology. 2015, 27(6): 455-464.

  6. Hui Chen, Yong Zhao*,Peng Shang*. The distinctive sensitivity to microgravity of immune cell subpopulations,MicrogravityScience and Technology. 2015,27(6): 1-10.

  7. Chong-Zhen Wang, PengShang*, Yong Zhao*. Microgravity activates p38 MAPK-C/EBPβ pathway to regulatethe expression of arginase and inflammatory cytokines in macrophages. InflammationResearch, 2015, 64: 301-311.

  8. Yang Wang, Peng Shang*,Air-Rong Qian*. GeneChip expression profiling reveals the alterations of energymetabolism related genes in osteocytes under large gradient high magneticfields.PLoS One, 2015, 10(1):e0116359.

  9. Li-Fang Hu, Peng Shang*.Mineralization initiation of MC3T3-E1 preosteoblast is suppressed undersimulated microgravity condition. Cell Biology International, 2015, 39(4): 364-372.

  10. Hui-Yun Xu, Sumin Gu,Manuel A. Riquelme, Sirisha Burra, Danielle Callaway, Hong-Yun Cheng, TejaGuda, James Schmitz, Roberto J. Fajardo, Sherry L. Werner, Hong Zhao, PengShang, Mark L. Johnson, Lynda F. Bonewald, Jean X. Jiang*. Connexin 43 channelsare essential for normal bone structure and osteocyte viability. Journalof Bone and Mineral Research, 2015, 30(3): 436-448.

  11. Yu-Long Sun, Zhi-Hao Chen,Xiao-Hu Chen, Chong Yin, Di-Jie Li, Xiao-Li Ma, Fan Zhao, Ge Zhang, Peng Shang,Ai-Rong Qian. Diamagnetic levitation promotes osteoclast differentiation fromRAW264.7 cells.IEEE Transactions on Biomedical Engineering, 2015, 62(3):900-8.

  12. Yu-Long Sun, Xiaohu Chen,Zhihao Chen, Xiaoli Ma, Dijie Li, Peng Shang, Ai-Rong Qian*. Neuropeptide FFattenuates RANKL-induced differentiation of RAW264.7 cells into osteoclast-likecells. Archives of Oral Biology, 60:282-292, 2015.

  13. Ting Huyan, Optimizedexpression and purification of humbug in pichia pastoris and its monoclonalantibody preparation. Iranian Journal of Public Health,2015, 44(12): 1632-1642.

  14. Ting Huyan, Heat shockprotein 90 inhibitors induce functional inhibition of human natural killercells in a dose-dependent manner. Immunopharmacol Immunotoxicol, 2015,38(2): 1-10.

  15. Ting Huyan, Qi Li ,Dan-Dan Dong, Hui Yang, Xiao-Ping Xue, Qing-Sheng Huang, Da-Chuan Yin. Developmentof a novel anti-Human aspartyl-(asparaginyl) β-hydroxylase monoclonal antibodywith diagnostic and therapeutic potential. Oncology Letters, 2015, In press.


二、中文期刊论文

  1. 商澎, 呼延霆,等,中国空间站生命科学研究展望,载人航天2015, 21(1): 1-5.

  2. 商澎, 呼延霆,等,中国空间生命科学的关键科学问题和发展方向,中国科学技术科学2015, 45(8):776-808.

  3. 宋双红, 商澎*, 等,骨碎补防治骨质疏松研究概况,生命的化学2015, 35(1): 73-80.

  4. 宋双红, 商澎*,柚皮素防治去卵巢致大鼠骨质疏松的实验研究,药学学报2015,50(2): 154-161.

  5. 商澎, 呼延霆, 杨周岐, 等,中国空间站生命科学研究展望, 载人航天, 2015, (1): 1-5.



2014年研究成果

一、英文期刊论文

  1. Peng-Fei Yang, KarstenEngel, Maximilian Sanno, Jens Dargel, Kilian Wegmann, Gert-Peter Brüggemann,Jörn Rittweger*, Tibia segment deformation is regulated by simulated muscleforces: a cadaveric study with a novel optical segment tracking (OST) approach.Journalof Musculoskeletal and Neuronal Interactions, 2014, 14(3): 267-275.

  2. Peng-Fei Yang, MaximilianSanno, Bergita Ganse, Timmo Koy, Gert-Peter Brüggemann, Lars Peter Müller, JörnRittweger*, Torsion and anteroposterior bending in the in vivo human tibia loading regimes during walking and running.PLoSOne, 2014, 9(4): e94525.

  3. Peng-Fei Yang, MaximilianSanno, Bergita Ganse, Timmo Koy, Gert-Peter Brüggemann, Lars Peter Müller, JörnRittweger*, In vivo application of anoptical segment tracking approach for bone loading regimes recording in humans:a reliability study. Medical Engineering & PShysics,2014, 36(8): 1041-6.

  4. Zhe Wang, Fengtao Hao,Chong Ding, Zhouqi Yang, Peng Shang*. Effects of static magnetic field on cell biomechanicalpropertyand membrane ultrastructure. Bioelectromagnetics, 2014, 35(4): 251-261.

  5. Jian Zhang, Chong Ding,Li Ren, Yimin Zhou, Peng Shang*. The effects of static magnetic fields on bone.Progressin Biophysics and Molecular Biology,2014, 114(3): 146-152.

  6. Ting Huyan, Qi Li, Da-ChuanYin*, Protective effect of polysaccharides on simulated microgravity-inducedfunctional inhibition of human NK cells.Carbohydrate Polymers, 2014,101(2): 819-827.

  7. Xianyuan Yang, Zhe Wang,Jian Zhang, Lifang Hu, Peng Shang*. Diamagnetic levitation of micro-carrier andMC3T3-E1 osteoblast cells affect cell morphology and functions. SpaceMedicine & Medical Engineering, 2014,27(6):

  8. Huiyun Xu, Ying Guan,Jiawei Wu, Jian Zhang, Jin Duan, Long An, Peng Shang*. Polycystin 2 is involvedin the nitric oxide production in responding to oscillating fluid shear inMLO-Y4 cells. Journal of Biomechanics, 2014,47(2): 387-391.

  9. Bin Jia, Li Xie, QiZheng, Peng-Fei Yang, Weiju Zhang, Peng Shang*. A hypomagnetic field aggravatesbone loss induced by hindlimb unloading in rat femurs. PLoS One, 2014, 9(8):e105604.

  10. Huiyun Xu, Jing Duan,Dandan Ning, Jingbao Li, Ruofei Liu, Ruixin Yang, Jean X. Jiang, Peng Shang*,The role of wnt signaling in fracture healing. BMB Reports, 2014,47(12): 666–672.

  11. Chong Ding, Bin Jia, XiLiu, Yi Lu, Jia Wang, Peng Shang*. Dielectric spectroscopy for evaluation ofthe influence of hypo-magnetic field and hind-limb unloading on the dielectricproperties of rat whole blood, spleen and testis. Space Medicine & MedicalEngineering, 2014, 27(3): 157-163.

  12. Chong Ding, Bin Jia, XiLiu, Yi Lu, Jia Wang, Peng Shang*. Effects of hypo-magnetic field and simulatedmicrogravity on dielectric properties of gastrocnemius in rats. SpaceMedicine & Medical Engineering, 2014, 27(1): 1-5.

  13. Jian Zhang, Chong Ding,Peng Shang*. Alterations of mineral elements in osteoblast duringdifferentiation under hypo, moderate and high static magnetic fields. BiologicalTrace Element Research, 2014,162(1-3): 153-157.


二、中文期刊论文

  1. 陈晓虎, 孙瑜隆, 骞爱荣, 李京宝,商澎,破骨细胞的形成和活化研究进展,中国细胞生物学学报2014,36(2): 258-266.

  2. 杨宪园,冯晓娜,丁冲,王哲,商澎*,羟基磷灰石微载体制备及生物相容性评价,材料导报2014, 2(8): 56-59.

  3. 关莹,续惠云,商澎,二维回转培养对MLO-Y4骨样细胞PKD3表达定位的影响,现代生物医学进展2014,14(14):2601-2605

  4. 王阳,骞爱荣,商澎,斯钙素在哺乳动物骨组织代谢中的作用. 中国生物化学与分子生物学报2014, 30(4): 343-348.

  5. 崔超, 呼延霆, 尹大川, 等,重组标签蛋白在蛋白质纯化中的研究进展,现代生物医学进展,2014, (32): 6372-6378.

  6. 任丽,续惠云,爱荣,商澎*,骨细胞微环境仿生模拟技术,生物化学与生物物理进展2014, 41(11): 1126-1134.




2013年研究成果

一、英文期刊论文

  1. Ming-Zhi Luo, Zhou-Qi Yang,Jing-Bao Li, Hui-Yun Xu, Sheng-Sheng Li, Wei Zhang, Airong Qian, Peng Shang. Calciuminflux through stretch-activated channels mediates microfilament reorganizationin osteoblasts under simulated weightlessness.Advances in Space Research, 51 (2013) 2058–2068.

  2. Ai-Rong Qian, Xiang Gao,Wei Zhang, Jing-Bao Li, Yang Wang, Sheng-Meng Di, Li-Fang Hu, Peng Shang. Largegradient high magnetic fields affect osteoblast ultrastructure and function by disruptingcollagen I or fibronectin/αβ1 integrin. PLoS One,2013, 8(8):e51036-e51036.

  3. Ai-Rong Qian, Da-ChuanYin, Peng-Fei Yang, Yi Lv, Zong-Cheng Tian, Peng Shang. Application ofdiamagnetic levitation technology in biological sciences research. IEEETransactions on Applied Superconductivity, 2013, 23(1):3600305.

  4. Mingliang Jin, QingshengHuang, Ke Zhao, Peng Shang. Biological activities and potential health benefiteffects of polysaccharides isolated from Lycium barbarum L. InternationalJournal of Biological Macromolecules,2013, 54(3):16-23.

  5. Li-Fang Hu, Ai-Rong Qian,Yang Wang, Sheng-Meng Di, Peng Shang. Inhibitory effect of simulatedmicrogravity on differentiating preosteoblasts. Advances in Space Research, 2013,51(1): 107-114.


二、中文期刊论文

  1. 李京宝, 蔺潇, 周虹,糖皮质激素与骨,中华骨质疏松和骨矿盐疾病杂志2013,6(4): 283-292.

  2. 丁冲, 谢丽, 商澎,石墨炉原子吸收法测定细胞中铁、铜、锰微量元素含量,化学与生物工程2013, 30(11): 71-73.

  3. 胡丽芳,骞爱荣,李迪杰,李京宝,商澎,不同分化阶段的成骨细胞对强磁重力环境的响应.中国细胞生物学学报2013, 35(7): 950-957.

  4. 吕毅, 倪云鹿, 商澎,基于灰度共生矩阵的植物细胞微管骨架纹理分析, 中国细胞生物学报 2013, 35(5): 690-696.

  5. 骞爱荣,李迪杰,商澎,天然反义转录物生物学功能及意义,中国细胞生物学学报2013,35(4): 536-542.

  6. 谢丽,孟芮,商澎,细胞共培养技术在骨组织生物学中的应用,中国细胞生物学学报2013,35(2): 216-223.

  7. 丁冲,陈晓虎,李迪杰,宁旦旦,商澎,骨组织生物磁性及磁场生物学效应研究,常州大学学报(自然科学版)2013, 25(1): 21-24.


三、专利

  发明专利

  1. 商澎,罗明志,谭映军,狄升蒙,丁冲,王哲,吕毅,一种新型细胞培养装置,专利号:201010258334.0(授权日期:2013.04.24


 实用新型专利

  1. 李京宝, 商澎, 王亮, 李亚楠, 杨宪园, 王蒙, 骞爱荣,一种用于贴壁细胞超重力环境的加载装置,专利号:ZL201220170963.2(授权日期:2013.04.03


四、专著章节

  1. 杨鹏飞,朱战霞,商澎,第二章:失重飞机实验,《航天器操作的微重力环境构建》,朱战霞,袁建平,等,著,中国宇航出版社,2013



2012年研究成果

一、英文期刊论文

  1. Jvfen Yan, Peng Shang, DeZheng, Yuan-Yuan Dong, Jun Mao, Suping Wang, Xin Liu, Shulin Yang. Effect of simulatedspace gravity environment on gibberella moniliformis EZG0807.CurrentMicrobiology, 2012,64(5):469-476.

  2. Ai-Rong Qian, Dong Li, JingHan, Xiang Gao, Sheng-Meng Di, Wei Zhang, Li-Fang Hu Li-Fang, Peng Shang.Fractal dimension as a measure of altered actin cytoskeleton in MC3T3-E1 cellsunder simulated microgravity using 3-D/2-D clinostats. IEEE Transactions On BiomedicalEngineering, 2012,59(5):1374-1380.

  3. Ai-Rong Qian, Liang Wang,Xiang Gao, Wei Zhang, Li-Fang Hu, Jing Han, Jing-Bao Li, Sheng-Meng Di, PengShang. Diamagnetic Levitation Causes Changes in the Morphology, Cytoskeletonand Focal Adhesion Proteins in Osteocytes. IEEE Transactions On Biomedical Engineering, 2012,59(1):68-77.

  4. Hui-Yun Xu, Jia-Wei Wu,Yuan-Yuan Weng, Jian Zhang, Peng Shang. two-dimensional clinorotationinfluences cellular morphology, cytoskeleton and secretion of MLO-Y4osteocyte-like cells.Biologia, 2012,67(1):255-262.

  5. Sheng-Meng Di, Rui Meng,Ai-Rong Qian, Zong-Cheng Tian, Jing-Bao Li, Rong Zhang, Peng Shang, Impact of osteoclastprecursors subjected to random positioning machine on osteoblasts.Journalof Mechanics in Medicine and Biology,2012, 4(12)

  6. Sheng-Meng Di, Zong-ChengTian, Ai-Rong Qian, Jing-Bao Li, Jia-Wei Wu, Zhe Wang, Da-Yu Zhang, Da-ChuanYin, Brandi ML, Peng Shang: Large gradient high magnetic field affects FLG29.1cells differentiation to form osteoclast-like cells.InternationalJournal of Radiation Biology, 2012, 88(11):806-813.

  7. Ming-Liang Jin, Ke Zhao,Qing-Sheng Huang, Chun-Lan Xu, Peng Shang. Isolation, structure andbioactivities of the polysaccharides from Angelica sinensis (Oliv.) Diels: Areview. Carbohydrate Polymers,2012, 89: 713-722.

  8. Hui-Yun Xu, Jian Zhang,Jia-Wei Wu, Ying Guan, Yuan-Yuan Weng, Peng Shang. Oscillatory fluid flowelicits changes in morphology, cytoskeleton and integrin-associated moleculesin MLO-Y4 cells, but not in MC3T3-E1 cells. BiologicalReserch2012,45(2):163-169.

  9. Ting Hu-Yan, Chen-YanZhang, Xiao-Liang Ma, et al. Progresses on crystallization methodology of membraneproteins, Progress in Biochemistry and Biophysics, 2012, 39(2): 126-136.

  10. Ai-Rong Qian, Ying Wang,Dong Li, Peng Shang. The role of calponin in cell mechanotransduction. RecentAdvances in Mechanobiology,2012, 157-160.


二、中文期刊论文

  1. 张蓉,田宗成,商澎,破骨细胞伪足小体的结构和功能,中国细胞生物学学报2012,34(2): 179–184.

  2. 杨宪园,丁冲,王哲,王林杰,商澎, 血清和尿液中钙离子浓度作为骨丢失评价指标的初步探讨,航天医学与医学工程2012,25(5): 317-321.

  3. 狄升蒙,田宗成,高翔,骞爱荣,MariaLuisa Brandi,商澎,随机定位模拟失重促进人前破骨细胞增殖和分化,航天医学与医学工程2012,25(1): 13-17.

  4. 刘宗琳,骞爱荣,商澎,微管微丝交联因子1与细胞骨架,细胞与分子免疫学杂志2012,28(2): 209-211.

  5. 李鹏辉,田宗成,商澎,破骨细胞骨吸收功能的检测方法,生物学杂志2012,29(4): 74-77.

  6. 张健,续惠云,乌佳伟,关莹,商澎,骨组织细胞Cx43形成的间隙连接及半通道研究进展,中国细胞生物学学报2012,34(7): 721-725.

  7. 于丹,骞爱荣,商澎,H2-calponin在细胞力学信号感知中的作用,生命的化学2012, 32(2): 107-110.

  8. 林煜,刘宗琳,骞爱荣,商澎,一种模拟失重性骨丢失小鼠尾悬吊模型的建立,航天医学与医学工程2012,25(4): 239-242.


三、发明专利

  1. 李京宝,商澎,王亮,李亚楠,杨宪园,王蒙,骞爱荣,一种用于贴壁细胞超重力环境的加载装置,申请号:201210118100.5(申请日期:2012.04.19),公开号:CN102643740A(公开日期:2012.08.22)

  2. 李京宝,商澎,王蒙,王佳,李亚楠,骞爱荣,一种利用细胞脱壁试剂评测细胞脱壁强度的方法,申请号:201210199358.2(申请日期:2012.06.18

  3. 李京宝,商澎,李亚楠,骞爱荣,过滤染色计数细胞的方法及装置,专利号:ZL201110100618.1(授权日期:2012.12.19

  4. 商澎,李京宝,何刚,王亮,骞爱荣,利用戊二醛诱发红外荧光测定溶液蛋白质浓度的方法,专利号:ZL201010171490.3(授权日:2012.08.01



2011年研究成果

一、英文期刊论文

  1. Hai-Fang Wang, Suzanne RYoung, Rita Gerard-O'Riley, Julia M Hum, Zhou-Qi Yang, Joseph P Bidwell,Fredrick M Pavalko . Blockade of TNFR1 signaling: A role of oscillatory fluidshear stress in osteoblasts. Journal of Cellular Physiology, 2011,226(4): 1044-1051

  2. Ming-Zhi Luo, Rui Meng,Sheng-Sheng Li, Sheng-Meng Di, Jing Han, Wei Zhang, Peng Shang. Weightlessness simulatedwith random positioning machine influences the cytoskeleton and migration ofMC3T3-E1 cells. J. Jpn. Soc. Microgravity Appl, 2011,(2):41-45.

  3. Hui-Yun Xu, Yuan-YuanWeng, Long An, Jian Zhang, Peng Shang. Effects of clinostat culture onmorphology and gene expression of MLO-Y4 osteocyte-like cells. J JpnSoc Microgravity Appl,2011,28(2):S31-S35.

  4. Jing-Bao Li, Liang Wang,Gang He, Ming-Zhi Luo, Ai-Rong Qian, Peng Shang, Fibronectin is involved ingravity-sensing of osteoblast like cell , J. Jpn. Soc.Microgravity Appl,2011,28( 2):S36–S40.

  5. Sheng-Meng Di,,Zong-Cheng Tian, Ai-Rong Qian, Xiang Gao, Dan Yu, Maria Luisa Brandi, PengShang*. Selection of suitable reference genes from bone cells in large gradienthigh magnetic field based on GeNorm algorithm. Electromagnetic Biology andMedicine, 2011,30(4):261-269.

  6. S. Liu*, F. Pan, Z. Wang, F. Wang, L.Rong, P. Shang** and W. Xiao***,Long-term quantitative phase-contrast imagingof living cells by digital holographic microscopy, Laser Physics, 2011,(4):740-745 (Co-Author)

  7. Sheng-Meng Di, Ai-Rong Qian, Li-Na. Qu,Wei Zhang, Zhe Wang, Chong Ding, Ying-Hui Li, Peng Shang *,Graviresponses of osteocytesunder altered gravity. Advances in Space Research, 2011,48 (6):1161-1166.

  8. Peng Jiang, Jing-Bao Li,Feng Han, Gao-Fei Duan, Xin-Zhi Lu, Yuchao Gu, Wengong Yu* , AntibiofilmActivity of an Exopolysaccharide from marine bacterium vibrio sp. QY101, PLoSOne, 2011,6(4):e18514.doi:

  9. Shuang Lu, Zong-ChengTian, Yi Lu, Peng Shang*, Preparation and characterization of the polyclonalantibody against GAR domain of microtubule actin cross-linking factor 1(MACF1). African Journal of Biotechnology,2011,10(11):2156-2162.

  10. P.F. Yang*, G-P.Brüggemann, J. Rittweger. What do we currently know from in vivo bone strain measurements in humans? Journal of Musculoskeletal & NeuronalInteractions, 2011, 11(1):8-20.

  11. Rui Meng, Hui-Yun Xu,Sheng-Meng Di, Dong-Yan Shi, Ai-Rong Qian, Jin-Fu Wang, Peng Shang*. Human mesenchymalstem cells are sensitive to abnormal gravity and exihibit classic apoptotic features.ActaBiochimica et Biophysica Sinica, 2011, 43(2):133-142.


二、中文期刊论文

  1. 贾斌,张卫菊,谢丽,郑琪,田宗成,骞爱荣,商澎,亚磁场环境对小鼠血液系统的影响.航天医学与医学工程2011, 24(5): 318-324.

  2. 胡丽芳,骞爱荣,商澎*,骨硬化蛋白与骨代谢,生命的化学2011, 31(5): 613-618.

  3. 王磊,曹军,骞爱荣,狄升蒙,王哲,杨周岐,模拟失重对人牙周膜成纤维细胞生物学性能的影响,航天医学与医学工程2011,24(2): 96-99.Co-Author

  4. 李胜胜,骞爱荣,罗明志,商澎*,钙调蛋白激酶对细胞生理功能的调节作用,生命的化学2011, 31(1): 95-101.


三、专利

发明专利

  1. 商澎,骞爱荣,杨鹏飞,丁冲,王哲,三维培养条件下细胞应变加载装置,专利号:ZL200810017367.9(授权日期:2011.09.14

  2. 商澎,尹大川,骞爱荣,贾斌,施朝华,薛小平,傅增祥,贾斌,田宗成,郑旭初,张维,大梯度强磁场中进行空间重力生物学模拟实验装置,授权号:ZL200610104905.9(授权日期:2011.11.30


实用新型专利

  1. 商澎,杨宪园,施朝华,王哲,狄升蒙,丁冲,贾国良,一种气体调温调湿装置,专利号:ZL201120573274.1

  2. 商澎,杨宪园,丁冲,一种便携式数字直读钙离子计,申请号:201120479479.3(申请日期:2011.11.25

  3. 李京宝,商澎,李亚楠,骞爱荣,过滤染色计数细胞的装置,申请号:201120119330.4(申请日期:2011.04.21专利号:ZL201120119330.4(授权日期:2011.12.14



2010年研究成果

一、英文期刊论文

  1. Hong Gao, Mei Liu, YingZhuo, Xian-Long Zhou, Jin-Tao Liu, Di-Fei Chen, Wen-Quan Zhang, Zhong-Xuan Gou,Peng Shang, and Li-Xin Zhang*, Assessing the potential of an induced-mutation strategyfor avermectin overproducers. Applied and Environmental Microbiology, 2010, 76(13):4583-4586 (Co-Author).

  2. Dong-Yan Shi, Rui Meng,Wang-Long Deng, Wen-Chao Ding, Qiang Zheng, Wen-Ji Yuan, Liyue Liu, Chen Zong,Peng Shang*, Jin-Fu Wang*. Effects of microgravity modeled by large gradient highmagnetic field on the osteogenic initiation of human mesenchymal stem cells. StemCell Reviews and Reports,2010, 6(4):567-578(Co-Author).

  3. Zhou-Qi Yang, BidwellJoseph P, Young Suzanne R, Gerard-ORiley Rita, Hai-Fang Wang, Pavalko FredrickM*. Nmp4/CIZ inhibits mechanically induced beta-catenin signaling activity inosteoblasts. Journal of Cellular Physiology, 2010, 223(2):435-41.

  4. Ai-Rong Qian, Peng-FeiYang, Li-Fang Hu, Wei Zhang, Sheng-Meng Di, Zhe Wang, Xiang Gao, Peng Shang*.High magnetic gradient environment causes alterations of cytoskeleton and cytoskeletonassociated genes in human osteoblasts cultured in vitro. Advance in Space Research, 2010,46:687-700.

  5. Jing-Bao Li, Zhe Wang,Gang He, Wei Zhang, Ai-Rong Qian, Peng Shang*. Application of glutaraldehyde toin-cell Western assay for normalization.Analytical Biochemistry, 2010,398:254–256.

  6. Zong-Cheng Tian, Mu-WangLi, Ai-Rong Qian, Hui-Yun Xu, Zhe Wang, Sheng-Meng Di, Peng-Fei Yang, Li-Fang Hu,Chong Ding, Wei Zhang, Ming-Zhi Luo, Jing Han, Xiang Gao,Yong-Ping Huang*, PengShang*. Effects of high magneto-gravitational environment on silkworm embryogenesis.MicrogravityScience And Technology, 2010,22:163-170.


二、中文期刊论文

  1. 瓮媛媛,续惠云,安龙,商澎*,骨样细胞MLO-Y4与成骨样细胞MC3T3-E1生物学特性的比较,中国细胞生物学学报2010, 32(4): 261-267.

  2. 丁冲,杨宪园,杨鹏飞,商澎*,关于机械振动对抗骨量丢失的研究进展,中华物理医学与康复杂志2010, 32(10): 795-797.

  3. 何刚,李京宝,王亮,商澎,骞爱荣*,戊二醛诱发红外荧光用于凝胶中蛋白质的检测与定量,中国细胞生物学学报2010,32(6): 893-896.

  4. 刘佳,田宗成,骞爱荣,商澎*MACF1相互作用蛋白的生物信息学研究,中国细胞生物学学报2010, 32(1): 131-136.

  5. 张维,骞爱荣,高翔,胡丽芳,瓮媛媛,韩晶,商澎*,细胞骨架染色中不同固定方法的探讨,中国细胞生物学学报2010,32(1):149-154.

  6. 曹建平,尹大川,骞爱荣,田宗成,续惠云,黄勇平,商澎*,抗磁性物质磁悬浮方法在空间生物学与生物技术中的应用,空间科学学报2011,31(1): 63-72.

  7. 吕毅,骞爱荣,商澎*,细胞骨架在植物感受和感知中的作用研究进展,西北植物学报2010,30(8): 1707- 1715.

  8. 续惠云,瓮媛媛,安龙,张健,商澎*,流体剪切力对骨组织细胞作用的研究进展,北京生物医学工程2010, 29(3): 318-322.

  9. 罗明志,李京宝,李胜胜,曹建平,孟芮,张维,商澎*,人骨肉瘤MG-63细胞自分泌可溶性纤连蛋白参与细胞形态维持,细胞与分子免疫学杂志2010:26(12): 1210-1213.

  10. 孟芮,罗明志,王亮,高翔,狄升蒙,商澎*,三维回转骨细胞培养条件对成骨细胞功能的调节作用,中国生物化学与分子生物学报2010,26(2): 95-102.

  11. 杨周岐,Pavalko Fredrick M.,商澎*Nmp4促进TNF-α诱导的成骨细胞凋亡,中国生物化学与分子生物学报2010,26(9): 828- 835.

  12. 杨周岐,商澎*Nmp4/CIZ对成骨细胞功能的调节作用,中国生物化学与分子生物学报2010,26(6): 498-504.

  13. 罗明志,曹建平,李胜胜,商澎*,三维回转培养动物细胞模拟失重生物效应研究进展,航天医学与医学工程2010,23(4): 299-303.

  14. 安龙,续惠云,瓮媛媛,商澎*,小鼠骨样细胞MLO-Y4 转染方法的研究,生物学杂志2010, 21(6): 87-94.

  15. 曹建平,骞爱荣,张维,商澎*0.2-0.4T静磁场对肿瘤细胞生长和黏附功能的影响,世界华人消化杂志2010, 18(13): 1337-1343.

  16. 骞爱荣,胡丽芳,狄升蒙,高翔,孟芮,商澎*,骨细胞在力学信号感受过程中的作用,中华航空航天医学杂志2010,2(21): 149-154.

  17. 呼延霆, 尹大川, 王伟, , 人类天冬胺酰基β-羟化酶的表达及其单克隆抗体的制备, 生物工程学报2011, 22(5): 341-346.


三、专利

发明专利

  1. 商澎,续惠云,张健,施朝华,瓮媛媛,杨鹏飞,李京宝,杨周岐,杨宪园,一种对贴壁细胞施加振荡性恒定流体剪切力作用的装置,申请号:201010131955.2(申请日期:2010.03.25公开号:101818117A(公开日期:2010.09.01

  2. 商澎,李京宝,骞爱荣,王哲,张维,田宗成,续惠云,谢丽,一种细胞计数的方法,授权号:ZL200810231880.8(授权日期:2010.12.01

  3. 商澎,骞爱荣,贾斌,杨鹏飞,王哲,丁冲,范明月,预防和治疗空间失重性骨丢失的装置,授权号:ZL200610105222.5(授权日期:2010.3

实用新型专利

  1. 商澎,续惠云,张健,施朝华,瓮媛媛,杨鹏飞,李京宝,杨周岐,杨宪园,一种对贴壁细胞施加振荡性恒定流体剪切力作用的装置,专利号:ZL201020141909.6


四、专著章节

  1. 李京宝,商澎,人工舱室环境耐受能力的生理学基础和生物学指标,“10000个科学难题生物学编委会,《10000个科学难题生物学卷》,科学出版社,2010



2009年研究成果

一、英文期刊论文

  1. Airong Qian, Lifang Hu,Xiang Gao, Wei Zhang, Shengmeng Di, Zongcheng Tian, Dachuan Yin, Yuanyuan Weng,Peng Shang*. Large gradient high magnetic field affects the association ofMACF1 with actin and microtubule cytoskeleton. Bioelectromagnetics, 2009, 30(7): 545-555.

  2. Airong Qian, ShengmengDi, Xiang Gao, Wei Zhang, Zongcheng Tian, Jingbao Li, Lifang Hu, Pengfei Yang,Dachuan Yin, Peng Shang*. cDNA Microarray reveals the alterations of cytoskeleton– related genes in osteoblast magneto-gravitational environment. ActaBiochimica et Biophysica Sinica,2009, 41(7): 561-577.

  3. Airong Qian, Dachuan Yin,Pengfei Yang, Bin Jia, Wei Zhang, Peng Shang*. Development of a Ground-based simulatedexperimental platform for gravitational biology. IEEE Transactions On AppliedSuperconductivity, 2009,19(2): 42-46.

  4. Zhe Wang, Pengfei Yang,Huiyun Xu, Airong Qian, Lifang Hu, Peng Shang*. Inhibitory effects of agradient static magnetic field (0.2 T - 0.4 T) on normal angiogenesis. Bioelectromagnetics, 2009, 30(6): 446-453.

  5. Pengfei Yang, Lifang Hu,Zhe Wang, Chong Ding, Wei Zhang, Airong Qian, Peng Shang*. Inhibitory Effectsof moderate static magnetic field on leukemia.IEEE Transactions on Magnetics, 2009, 45(5): 2136-2139.

  6. Pengfei Yang, Bin Jia,Chong Ding, Zhe Wang, Airong Qian, Peng Shang*. Whole-body vibration effects onbone before and after hind-limb unloading in rats. Aviation Space &Environmental Medicine, 2009,80: 88-93.


二、中文期刊论文

  1. 李京宝,何刚,高翔,商澎*,比色法监测细胞培养基酸度,陕西师范大学学报(自然科学版)2009, 37(4): 64-66.

  2. 田宗成,骞爱荣,续惠云,狄升蒙,张维,瓮媛媛,商澎*,家蚕动力蛋白轻链8基因克隆及其对重力的响应,生物化学与生物物理进展2009,36(3): 364-370.

  3. 狄升蒙,田宗成,高翔,骞爱荣,商澎*,破骨细胞研究进展,细胞生物学杂志2009,31(6): 792-798.

  4. 高翔,骞爱荣,李京宝,商澎*In-cell WesternCell ELISA在大分子量蛋白质相对定量中的应,细胞生物学杂志2009,31(6): 882-886.

  5. 李京宝,续惠云,骞爱荣,商澎*,失重环境下的细胞外基质,细胞生物学杂志2009, 31(6): 799-804.

  6. 韩晶,骞爱荣,胡丽芳,王哲,于丹,张蓉,商澎*,基于免疫荧光图像的微管蛋白半定量分析,第四军医大学学报2009,30(24): 2901-2904.

  7. 李京宝,胡丽芳,张维,骞爱荣,商澎*In-Cell Western检测细胞纤连蛋白,第四军医大学学报2009,30(19): 1861-1863.

  8. 张维,骞爱荣,杨鹏飞,王哲,商澎*,一种新的检测鸡胚尿囊膜血管生成的方法,第四军医大学学报2009, 30: 1243-1245.

  9. 胡丽芳,骞爱荣,杨鹏飞,张维,谢丽,商澎*,中等强度静磁场对白血病细胞增殖和细胞周期的影响,第四军医大学学报2009,30(5): 397-400.

  10. 骞爱荣,张博,胡丽芳,张维,瓮媛媛,高翔,商澎*MACF1生物信息学分析及细胞定位,第四军医大学学报2009,30(1): 33-36.

  11. 胡丽芳,骞爱荣,商澎*Vinculin在细胞响应力学刺激中的作用,中国生物化学与分子生物学报2009,25(9): 805-810.

  12. 贾斌,商澎*,亚磁环境生物学效应的研究进展,航天医学与医学工程2009, 22(4): 308-312

  13. 丁冲,杨鹏飞,商澎*,用于预防和治疗骨丢失的机械振动装置,北京生物医学工程2009, 28(2): 165-169 .

  14. 孟芮,续惠云,王哲,张维,商澎*,骨细胞模拟失重条件培养基对成骨细胞的影响,航天医学与医学工程2009,22(4): 247-251.

  15. 骞爱荣,胡丽芳,张维,高翔,商澎*MACF1与成骨细胞骨架之间的相互关系研究,生命科学研究2009, 13(5): 382-387.



2008年研究成果

一、英文期刊论文

  1. Airong Qian, Wei Zhang,Yuanyuan Weng, Zongcheng Tian, Shengmeng Di, Pengfei Yang, Dachuan Yin, LifangHu, Zhe Wang, Huiyun Xu, Peng Shang*. Gravitational environment produced by asuperconducting magnet affects osteoblast morphology and functions.ActaAstronautica, 2008, 63: 929-946.

  2. Airong Qian,Wei Zhang, LiXie,Yuanyuan Weng, Pengfei Yang, Zhe Wang, Lifang Hu, Huiyun Xu, ZongchengTian, Peng Shang*. Simulated weightlessness alters biological characteristicsof human breast cancer cell line MCF-7. Acta Astronautica. 2008, 63:947-958.

  3. Airong Qian,Wei Zhang,Jianping Cao, Pengfei Yang, Xiang Gao, Zhe Wang, Huiyun Xu, Yuanyuan Weng, PengShang*. Downregulation of CD147 expression alters cytoskeleton architecture andinhibits gelatinase production and SAPK pathway in human hepatocellularcarcinoma cells.Journal of Experimental & Clinical Cancer Research, 2008,27(1): 50.

  4. Airong Qian, Wei Zhang,Yuanyuan Weng, Peng Shang*. Stealth siRNA against CD147 inhibits hepatocellularcarcinoma cell metastatic properties. Biologia. 2008, 63(5): 756-763. 223922


二、中文期刊论文

  1. 狄升蒙,骞爱荣,田宗成,张维,胡丽芳,尹大川,续惠云,瓮媛媛,商澎*,强磁重力环境对人成骨细胞发动蛋白-2表达和定位的影响,细胞生物学杂志2008,30(6): 766-770.

  2. 续惠云,安龙,王哲,曹建平,商澎*,模拟失重对人成骨样细胞凋亡的影响,细胞生物学杂志2008, 30(5): 651-654.

  3. 骞爱荣,张维,瓮媛媛,杨鹏飞,王哲,商澎*,强磁重力环境对成骨细胞增殖、形态及其主要元素含量的影响,第四军医大学学报2008,29(19): 1729-1732.

  4. 孟芮,王海芳,续惠云,骞爱荣,曹建平,商澎*,骨细胞功能研究进展,细胞生物学杂志2008,30(2): 161-165.

  5. 骞爱荣,胡丽芳,商澎*,微管微丝交联因子1的结构与功能,细胞生物学杂志2008, 30(2): 187190.

  6. 续惠云,王海芳,孟芮,曹建平,田宗成,商澎*,深空辐射生物学效应研究进展,航天医学与医学工程2008,21(5): 451-454.

  7. 续惠云,罗明志,孟芮,张维,高翔,李文建2,商澎*12C6+离子辐射对细胞存活增殖及模拟失重和辐射对家蚕卵发育的影响,第四军医大学学报2008,17: 1551-1554. 2中国科学院近代物理研究所,甘肃兰州)

  8. 田宗成,周博2,骞爱荣,续惠云,狄升蒙,赵云坡2,章玉萍2,刘佳,黄勇平2,商澎*,家蚕3-羟基异丁酸脱氢酶基因克隆及其在模拟失重环境中的表达模式分析,生物工程学报2008,24(12): 1-9. 2中国科学院上海生命科学研究院植物生理生态研究所,上海)

  9. 田宗成,周博2,骞爱荣,续惠云,刘佳,狄升蒙,张维,瓮媛媛,黄勇平2,商澎*,家蚕胚胎期重力相关基因的抑制消减杂交分析,中国生物工程杂志2008,28 (11): 25-31. 2中国科学院上海生命科学研究院植物生理生态研究所,上海)


三、实用新型专利

  1. 商澎,骞爱荣,杨鹏飞,丁冲,王哲,三维培养条件下大作用力细胞应变加载装置,专利号:ZL200820028172.X

  2. 商澎,骞爱荣,杨鹏飞,丁冲,王哲,三维培养条件下大位移细胞应变加载装置,专利号:ZL200820028171.5



2007年研究成果

一、发明专利

  1. 商澎,骞爱荣,杨鹏飞,王哲,贾斌,张维,利用磁场调节免疫功能的装置及方法,申请号:200610104880.2(申请日期:2006.11.09公开号:CN1966105(公开日期:2007.05.23



2006年研究成果

一、中文期刊论文

  1. 孙怡宁,商澎*,梅其炳*,微重力引起骨丢失的细胞机制,国际骨科学杂志2006, 27(2): 126-128.